Antitumor and antileishmanial activities of limonene-thiosemicarbazones bearing heterocycles nucleous

In the present study, we provided synthesis of a series R-(+)- and S-(-)-limonene-based thiosemicarbazones containing different pentacyclic heterocyclic nucleus moiety focused in search novel antitumor antileishmanial agents. assay, derivative imidazole S-(-)-limonene 8 was most active compound, especially for U-251, UACC-62 K562 human tumor cell lines with GI50 ranging from 1.0 to <0.25 µg.mL-1. On other hand, imidazole-thiosemicarbazone R-(+)-limonene 4 promising against promastigote form L. amazonensis (IC50=5.9µM). Meanwhile, without limonene (9-12) showed lowest activities biological assays performed. The results demonstrated influence lipophilic molecular character stereochemistry chiral monoterpene on evaluated activities.